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The Disparity of Angiotensinogen M235T Polymorphism in Patients with Major Depressive Disorder and Hypertension

Author(s): Wei-Tsung Kao, Chen-Lin Chang, For-Wey Lung


Objective: This study aimed to investigate variations in angiotensinogen (AGT) M235T polymorphism among patients with major depressive disorder (MDD) and hypertension.

Methods: This study recruited 101 patients with MDD, 100 with hypertension, 35 with both MDD and hypertension, and 572 community controls.

Results: The frequency of MM genotype of AGT M235T polymorphism was highest in patients with both MDD and hypertension, second highest in patients with MDD, third highest in patients with hypertension and lowest in control participants. The same trend was seen for the frequency of M235 allele and M genotype of AGT M235T polymorphism. In addition, patients with both MDD and hypertension had a 2.027 times risk of having an M genotype of AGT M235T polymorphism, and patients with only MDD had a 1.712 times risk, and patients only with hypertension had a 1.242 times risk.

Conclusion: The AGT M235T polymorphism may have a pleiotropic effect in depression and hypertension. The depressive symptoms, hypertension medication and age of onset should be considered in the clinical setting. A population-based study should be needed for further clarification to the results in future studies.

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