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Pharmacophore Screening and Docking studies of AMPA Receptor Implicated in Alzheimer��?s disease with Some CNS Acting Phytocompounds from Selected Ayurvedic Medicinal Plants

Author(s): Preenon Bagchi, Anuradha M, Ajit Kar

Neuro-degeneration including dementia in Alzheimer ’s disease (AD) is an global alarming problem. AD accounts for 60 to 80 percent of dementia cases. AMPA (alpha-amino-3-hydroxy- 5-methyl-4-isoxazole propionic acid) receptors are the main contributors of excitatory neurotransmission, mediating the fast, rapidly desensitizing excitation of many synapses, and are involved in the early response to glutamate in the synaptic space. The gene receptor AMPA responsible for AD is taken for this work. In the present study phyto-compounds from Ayurvedic Medicinal plants like Centella asiatica, Bacopa monnieri, Convolvulus pluricaulis, Mucuna pruriens, Ocimum sanctum, Tinospora cordifolia, Curcuma longa, Nardostachys jatamansi are among others used. The active components of the plants are taken and pharmacophore screening along with docking studies are performed against AMPA receptor in silico. The docking scores are noted for further in-vitro receptor-ligand binding assay studies. The selected phytocompounds were screened against AMPA receptor. Again, ADME (drug-like properties) was determined for the shortlisted ligands. Based on virtual screening, shortlisted ligands selected were Quercetin dihydrate and Asiatic acid.

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