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Abstract

Orthostatic Hypotension in Alzheimer’s disease: A Meta-Analysis

Author(s): Zhiyou Cai, Cheng-Qun Wan, Zunyu Ke, Yi Chen

Objective

To investigate the relationships between orthostatic hypotension (OH) and the risk of AD using meta-analysis.

Methods

The PubMed, Sciencedirect and Web of Science were searched to identify relevant literature published up to October 2016. The RevMan 5.3 software was used for statistical analysis, with odds ratio (OR), risk ratio (RR) and 95% confidence intervals (CI) calculated to evaluate the associations between OH and the risk of AD. Meta-regression and publication bias were also performed.

Results

This meta-analysis included 6 studies. OH was associated with increased AD risk (OR=8.27, 95% CI=4.21-16.22, P<0.00001; RR=8.27, 95% CI=3.15-10.55, P<0.00001). There was no heterogeneity (OR: P=0.54, I2=0%; RR: P=0.45, I2=0%). The funnel plots were symmetrical. Egger’s linear regression showed that there was no publication bias (P=0. 212).

Conclusion

This meta-analysis showed that OH may be a risk factor for susceptibility to AD. Large-sample multicenter studies are needed to confirm the findings.


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