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Neuropsychiatric Symptoms Associated With Limbic Argyrophilic Grains in Pallidonigroluysian Atrophy

Author(s): Yuji Tomizawa, Masashi Takanashi, Yoshiaki Furukawa

Pallidonigroluysian atrophy (PNLA) is a rare neurodegenerative disease that is pathologically defined by severe neuronal loss in the globus pallidus, substantia nigra, and subthalamic nucleus. In this article, we present the first PNLA case who had prominent psychiatric symptoms, including delusions, and demonstrated lots of limbic argyrophilic grains. Our findings expand the clinical spectrum of PNLA and suggest that salient neuropsychiatric symptoms in this disease could be caused by argyrophilic grains in the limbic system.

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