All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Increased levels of Serum Nitrogen oxides are indicators of Post-treatment response in Mood disorder patients with Acute episodes

Author(s): Chih-Wei Hsu, Tiao-Lai Huang, Meng-Chang Tsai


Nitrogen Oxides (NOx) has an important role in mood disorders. This study aims to investigate whether serum NOx levels are associated with bipolar disorder, manic episodes (BD-ME) and major depressive disorder, depressive episodes (MDD-DE), and to evaluate the impact of treatments on NOx levels and symptoms severity in BD-ME and MDD-DE patients.


We enrolled 20 patients with BD-ME, 18 with MDD-DE, and 80 healthy subjects. Serum NOx levels were measured with assay kits. Symptom severity was evaluated using the Young Mania Rating Scale (YMRS) for BD-ME and the Hamilton Depression Rating Scale (HAM-D) for MDDDE. We collected and analyzed patients’ NOx, YMRS, and HAM-D data while pre-treatment (admission) and post-treatment (discharge).


Serum NOx levels of the healthy controls were higher than patients with BD-ME and lower than patients with MDD-DE, but the difference was not statistically significant. Serum NOx levels were both increased in BD-ME (p=0.0047) and in MDD-DE (p=0.0398) patients after treatment. The changes of NOx levels were not associated with the changes of YMRS scores in BD-ME patients after treatment. However, the changes of NOx levels were negatively correlated with the changes of HAM-D scores in MDD patients after treatment (p=0.0473).


Our results suggest that increased levels of serum NOx are indicators in patients with BDME and MDD-DE after treatment. In addition, the changes of serum NOx levels might be measuring biomarkers for assessment of treatment response in MDD-DE patients.

Full-Text | PDF

Share this       

antalya escort

izmir rus escort

bursa escort bayan

antalya escort bayanlar

izmir escort

porno indir

porno izle

beşiktaş escort

eskişehir escort

burdur escort

bartın escort


türk takipçi satın al

izmir escort

bursa escort

türk porno

escort bayan

yabanci porno

takipçi satın al

takipçi satın al

instagram takipçi satın al

instagram beğeni satın al

instagram takipçi satın al

takipçi satın alma


panel smm

takipçi satın al instagram

smm panel

ataköy escort

izmit escort

Ledger Live desktop: Your secure gateway to crypto. Secure your assets with confidence using Ledger Live desktop. Experience a secure gateway that prioritizes the safety of your digital assets, providing peace of mind.