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Effects of social stress on ethanol responsivity in adult mice

Author(s): Garcia-Pardo MP, Roger-Sanchez C, Rodriguez-Arias M, Minarro J, Aguilar MA

Exposure to stressors can produce behavioural and neurochemical adaptations that render individuals more prone to drug-seeking and drug-taking behaviours. Alcohol is the most consumed drug of abuse in the USA and Europe and binge drinking is becoming increasingly frequent. Stress experiences are a risk factor for alcohol abuse in humans and recent studies in animal models reported that repeated social stress increased alcohol consumption. The aim of the present work is to evaluate the acute or long-term effects of stress induced by social defeat (SD) on consumption of ethanol (ETOH 6%) using the two-bottle choice procedure and on place conditioning induced by this substance.

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