All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Broad Impairment of Executive Functions in Patients with Parkinson’s disease: A Meta-Analysis

Author(s): John SY Chan, Danxia Liang, Kanfeng Deng, Jiamin Wu, Liuyang Cai, Jin H Yan

Abstract

Objective: Executive functions (EF) impairments have been observed in patients with Parkinson’s disease (PD). However, the pattern of EF deficits in this population remains unclear. This article aimed to examine the influence of PD on different EF domains through meta-analysis of published data.

Methods: This article aimed to compare the EFs of PD patients with those of healthy controls (CON) in different EF domains. We searched electronic databases for articles reporting comparisons of EF performance between non-demented/non-depressed PD patients and CON. Accordingly, we identified 140 studies investigating 6 EF domains (attention, inhibition, planning, reasoning, shifting and working memory) in 4683 PD patients and 4247 CON.

 Results Results showed that PD patients exhibited impaired attention (Hedges’ g= -0.48), inhibition (Hedges’ g=-0.48), planning (Hedges’ g = -0.49), reasoning (Hedges’ g = -0.31), shifting (Hedges’ g = -0.55) and working memory (Hedges’ g = -0.53). They exhibited a moderately impaired overall EF (Hedges’ g = -0.49). EF deficits were not moderated by age, years of education, disease severity, motor deficits, disease duration, medication dose or global cognition.

Conclusions: The findings suggest that among PD patients, EFs in which reasoning is least affected are broadly impaired


Full-Text | PDF

Share this       
500 Internal Server Error

Internal Server Error

The server encountered an internal error or misconfiguration and was unable to complete your request.

Please contact the server administrator at [email protected] to inform them of the time this error occurred, and the actions you performed just before this error.

More information about this error may be available in the server error log.