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Abstract

Biased agonism at serotonin 5HT1A receptors: preferential postsynaptic activity for improved therapy of CNS disorders

Author(s): Adrian Newman-Tancredi

Serotonin or 5‑hydroxytryptamine (5‑HT)1A receptors are widely expressed in the brain and have extensive influence in the control of mood, cognition, movement and pain. In order to achieve optimal therapeutic benefit from targeting these receptors, ‘biased agonists’ (also known as ‘functionally selective agonists’) are desirable in order to preferentially activate receptor subpopulations in brain regions that mediate therapeutic activity, whilst avoiding those that control other effects.


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