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Research Article - (2018) Volume 8, Issue 3

The Mediating Effect of Depression in Religiosity and Cognitive Function among Chinese Muslim Elderly

Corresponding Author:
Zhizhong Wang
Department of Epidemiology, School of Public Health and Management, Ningxia Medical University, Yinchuan, 750004, China


The current study examined the association between religiosity and mild cognitive impairment (MCI), along with the mediating role of depression, in Chinese Muslim elderly sample. 1,347 community Muslims aged 55 years or older were recruited in Ningxia, China. The Mini- Mental State Exam, the Geriatric Depression Scale, and the Duke University Religion Index were administered. Structural equation modeling (SEM) was used to detect the mediation effect. Approximately 21.3% participants reported experiencing mild or severe depressive symptoms and 25.7% met criteria for MCI. Religiosity was associated with a lower risk of MCI (OR=0.83, P<0.05), while depression was associated with a greater risk of MCI (OR=1.70, P<0.01). SEM analysis revealed that depression significantly mediated the association between the religiosity and MCI with an effect ratio of 0.33 (explaining 33.0% of the total variance). In summary, religiosity was related to cognitive functioning partly due to its inverse relationship with depression in older Chinese Muslims.


Depressive, Mild cognitive impairment, Mediating effect, Religiosity, Muslim


It is estimated that by 2050 the number of population over the age of 60 will be 2 billion globally [1]. A negative consequence of the rapidly aging of world population is the increased prevalence of cognitive disorders; include dementia and mild cognitive impairment (MCI) [2]. The determinants of cognitive impairment include age, education, smoking, physical activity, and social engagement [3-5]. Besides the above factors, systematic reviews have shown that depression is associated with an increased risk of developing dementia [6] and cognitive decline [7]. Moreover, depression as a risk factor has been found interacted with genetic factors to increase risk of cognitive decline. Individuals with both depressive symptoms and one or more copies of the apolipoprotein E (APOE) 4 allele experience more cognitive decline than depressed persons without copies of the APOE4 allele, leading to a greater risk of Alzheimer disease (AD) [8]. Research has also indicated that depression by itself may increase the risk of dementia [9,10].

As a social determinant of health, religious involvement has been found contributed to a lower risk of cognitive decline [11-14]. A review of this research concluded that higher levels of religiosity in Alzheimer’s patients were associated with a slower rate of cognitive and behavioral decline, with a corresponding significant reduction in caregiver burden [15]. This was explained by an increase in social integration, better behavioral self-control [16], and fewer life event stresses among those who are religiously active [17]. Religious involvements have also been associated with lower depression prevalence [18,19], a 14 years follow-up study in Canada demonstrated that more religious involvements reduced risk of developing major depression by 22% [20].

What then is the relationship among religiosity, depression, and MCI or cognitive decline? Reyes- Ortiz et al examined how church attendance modified the effect of depressive symptoms on cognitive function in Mexican Americans. Among participants with high depressive symptoms, those infrequent church attendances experienced a greater decline in Mini-Mental State Examination (MMSE) scores than those frequent church attendances [21]. Most recently, Foong et al revealed that the intrinsic religiosity mediated the association between depression and cognitive function after controlling for selected wide range of socio-demographic characteristics [22]. However, much more needs to be known about this relationship. First, both above studies did not indicate how much depression mediated the association between religiosity and MCI. Raykov indicated that “If an indirect effect does not receive proper attention, the relationship between two variables of interest may not be fully considered” [23]. Second, the association between religion and mental health is robust across cultures. Most studies of religiosity and cognitive function were conducted in highly religious societies and in Christian populations. To our knowledge, little research has examined the relationship between religion and cognitive function, or how depression influences this relationship, in China where religion is less practiced and encouraged.

To address those gaps in the literature, the present study sought to examine the mediating effect of depressive symptoms on the relationship between religiosity and cognitive function using structural equation model in a communitydwelling sample of Chinese Muslims.


▪ Participants and field procedure

Participants in present study were acquired from Ningxia Hui Autonomous Region, a northwestern province of China, which has a population of 2.2 million residents of Hui ethnicity (constituting 36.1% of the total population in the province). This ethnic group is composed almost entirely of Muslims. A cluster sampling method was used to identify participants in this study. Three communities were contacted and agreed to participate in the face-to-face survey. Inclusion criteria for the participants were (1) individuals living in the selected communities for at least six months; (2) aged 55 years or older; and (3) having a verified Hui ethnicity identification card. Excluded were those with a history of psychosis, severe hearing loss, vision loss, and language barriers. Of a total of 1,665 community residents eligible for the survey, 1,347 (80.9% of the total sample) agreed to participate and completed the full questionnaire were included in the final analysis.

Face-to-face surveys were conducted by trained interviewers at the time they attended a health examination at community health care centers. The health examination is part of a public health service program supported by the local government. All those aged fifty years or older are eligible to receive free health examinations once a year at their local community health care centers.

▪ Ethical considerations

The study was conducted in accordance with the Helsinki Declaration, World Medical Association and approved by the Institutional Review Board at Ningxia Medical University (document number: 2015151). Written informed consent was obtained from all participants.

▪ Measurement

Sociodemographic information was collected including age, gender, marital status, living status (living alone or not), educational level, and occupation. The Activities of Daily Living Scale (ADL) was used to measure the physical function.

▪ Outcome variables

Cognitive function was measured using the Chinese version of the MMSE [24]. The MMSE is short, easy to administer, and has good reliability and validity as a screening tool for cognitive impairment [25]. The MMSE consists of 19 questions and has a score ranged from 0 to 30. It assesses five different domains of cognitive function: (1) orientation with a maximum of 10 points, (2) memory with a maximum of 6 points, (3) attention and calculation with a maximum of 5 points, (4) language with a maximum of 8 points, and (5) visuospatial constructional ability (copying intersecting pentagons) with the maximum of 1point. The determination of the normal score is closely related to the level of education of the subjects [26]. MCI was diagnosed according to Peterson’s criteria [27] with modification as Cui et al suggested: MMSE was used assessing normal cognitive function instead of verbal memory test, and the educational level was taken into account when determining cutoff as: For those who were illiterate with MMSE ≤ 17; for those with only a primary school education, the threshold was MMSE ≤ 20; for high school graduates or above, the threshold was MMSE ≤ 24 [28]. In addition, participants were asked the question “Have you had a significant decline in your memory recently?”

▪ Independent variables

Religiosity was measured using the Chinese version of the 5-item Duke University Religion Index (DUREL), a comprehensive and brief measure of organizational religious activity (OR), non-organizational religious activity (NOR), and intrinsic religiosity (IR). The DUREL has a total score range from 5 to 27, higher scores indicate higher level of religiosity [29]. The Chinese version of the DUREL is a reliable and valid measure of religious involvement that can be used to assess the relationship with physical and psychological well-being in Chinese respondents [30]. In the present study, high religiosity was defined as praying more than once a day and attending religious services at least once per week, and indicating that religion was important or very important in their life (i.e., corresponding to a DUREL total score >24) [31].

The Geriatric Depression Scale (GDS) was used to assess depressive symptoms. The GDS is a frequently used and well-validated screening measure for depression among older adults [32]. It consists of 30 self-report items that assess a broad range of depressive symptoms using a simple yes/ no response format. GDS scores ranged from 0 to 30, with higher score indicating more severe depressive symptom [33]. Regarding total score cutoffs, 0 to 9 indicates normal mood; 10 to 19 indicates mild depressive symptoms; and 20 to 30 indicates severe depressive symptoms [34]. The Chinese version of the GDS has been shown to be a reliable and valid measure of depression in rural and urban populations [35].

▪ Statistical methods

The differences in socio-demographic variables between participants with MCI and those with normal cognition were tested using the chi-square test for categorical variables, and the Student’s t test for age, the Wilcoxon rank-sum test for DUREL. Logistic regression models were used to examine the association among religiosity, depression and MCI. All analysis was performed using the SPSS 22.0 (IBM Corporation, Armonk, NY, USA), and significance level was set at p<0.05, with two-tailed test.

Structural equation modeling (SEM) coupled with the bias-corrected bootstrap method (2000 replicates) was employed to examine the mediating effect of depression on the relationship between religiosity and cognition function [36,37]. Post-hoc modifications were performed with reference to the modification index. A mediating effect model was used since the bootstrapping confidence intervals did not include zero [38]. Both the direct effect and mediating effect were estimated using AMOS version 21.0 (IBM Corporation, Armonk, NY, USA). Several indices of model fit were calculated, including the root mean square error of approximation (RMSEA), where less than 0.08 is acceptable; Goodness of Fit Index (GFI), where values larger than 0.90 indicate a good model fit; the Values of Comparative Fit Index (CFI) and the Tucker Lewis Index (TLI), where values of 0.90 or higher indicate acceptable fit.


▪ Demographic characteristics of participants

As displayed in Table 1, the average age of participants was 65.1 (SD=6.0) years, with a range from 55 to 84 years. Nearly half of participants was female (51.9%), and were illiterate (57.2%). Only 3.9% of participants lived alone, and most participants (96.2%) were married. 21.3% participants reported mild or severe depressive symptoms; concerning cognitive function, 25.7% met criteria for MCI. Participants with MCI were older than those without cognitive impairment, were more likely to be female, were more likely having depressive symptoms, and were less likely to score high on religiosity.

Variables Total
t/Chi P value
Age, mean (SD), years 65.1 (6.0) 65.2 (5.7) 64.2 (5.3) 6.84 <0.001
DUREL, mean (SD) 24.8 (3.5) 24.2 (4.1) 25.0 (3.2) 3.57 <0.001
Gender, female, n (%) 699 (51.9) 210 (60.7) 489 (48.9) 14.45 <0.001
Urban/rural, rural, n (%) 1,126 (83.7) 292 (25.9) 834 (74.1) 0.22 0.641
Education       31.62 <0.001
Illiterates, n (%) 770 (57.2) 163 (47.1) 607 (60.6)    
Primary school, n (%) 338 (25.1) 89 (25.7) 249 (24.9)
>Junior high school, n (%) 239 (17.7) 94 (27.2) 145 (14.5)
Living alone, yes, n (%) 52 (3.9) 17 (4.9) 35 (3.5) 1.39 0.238
Marriage time, >=2, n (%) 51(3.8) 14 (4.0) 37 (3.7) 0.09 0.769
Depressive symptoms       7.14 0.028
Normal mood, n (%) 1,060 (78.7) 255 (73.7) 805 (80.4)    
Mild depressive, n (%) 216 (16.0) 67 (19.4) 149 (14.9)
Severe depressive, n (%) 71 (5.3) 24 (6.9) 47 (4.7)
High Religiosity, yes, n (%) 1,042 (77.4) 246 (71.1) 796 (79.5) 10.41 0.001
Hypertension, yes, n (%) 429 (31.8) 112 (32.4) 317 (31.7) 0.05 0.809

Table 1: Demographic characteristics of the participants.

▪ Categorical analyses

As Table 2 shows, categorical analyses revealed that religiosity was inversely related to risk of MCI. In contrast, depression was positively associated with MCI (model 1). After controlling for socio-demographic variables, these findings persisted significant (model 2). The association between religiosity and MCI, however, disappeared when depression was controlled for in the model (model 3), indicating that depression fully mediated the relationship between religiosity and MCI.

Variables Model 1 Model 2 Model 3
P value OR (95%CI) P value OR (95%CI) P value OR (95%CI)
Religiosity (high) 0.001 0.63(0.48,0.83) 0.014 0.69 (0.52,0.93) 0.330 0.83 (0.57,1.20)
Depressive (yes) 0.009 1.46 (1.10,1.95) 0.020 1.42 (1.05,1.92) 0.039 1.70 (1.02,2.80)
Age (>=65 Year) NA NA <0.001 1.58 (1.22,2.04) 0.001 1.55 (1.20,2.01)
Education (illiterate) NA NA <0.001 0.39 (0.30,0.52) <0.001 0.39 (0.30,0.52)
gender (female) NA NA <0.001 2.29 (1.73,3.03) <0.001 2.23 (1.68,2.96)
Depressive ×Religiosity NA NA NA NA 0.244 0.68 (0.36,1.29)

Table 2: Logistic regression model for interaction between religiosity and depression on MCI (n=1,347).

▪ Analyses of continuous variables

The results of bivariate correlations when independent variables were left as continuous are presented in Table 3. After controlling for sociodemographic variables (age, gender, education), the DUREL score was positively correlated with MMSE score (P<0.001); the DUREL was negatively correlated with GDS score (P<0.001); and the GDS score was negatively correlated with MMSE score (P<0.001).

MMSE 22.7 4.5 1    
GDS 5.8 6.1 -0.274*** 1  
DUREL 24.8 3.5 0.099*** -0.290*** 1

Table 3: correlation matrix (n=1,347).

▪ SEM results for mediation effects

A mediation model was developed as shown in Figure 1. After the post-hoc modifications were performed, the final model yielded good fit of the data (x2 = 5.47, RMSEA = 0.058, GFI = 0.971, CFI = 0.943, TLI = 0.921, IFI=0.943, NFI=0.931). The total effect, direct effect and mediating effect of religiosity on cognitive function with standard errors and confidence intervals were obtained using the Bootstrap method. The results showed that the direct effect and the total mediating effect were significant (P<0.05). The mediation effect of depression in the relationship between religiosity and cognitive functioning accounted for 33.03% (0.179/0.542) of the total effect (Table 4). The PRODCLIN program test results showed that the 95% confidence interval for this mediation (0.117, 0.263) and the bias-corrected program test results indicate that the 95% confidence interval was (0.116, 0.260), all ranges do not include 0, indicating that the mediation paths was statistically significant.

Effect Point estimation Product of coefficients Bootstrapping
Bias-corrected Percentile 95%CI
SE Z Lower Upper Lower Upper
Total effect 0.542 0.117 4.63 0.346 0.825 0.343 0.818
Mediating effect 0.179 0.038 4.71 0.116 0.260 0.117 0.263
Direct effect 0.363 0.101 3.59 0.194 0.594 0.188 0.589

Table 4: The Mediating effect of depression on the relationship between religiosity and MCI (n=1,347).


Figure 1: The mediation model of depression in the relationship between religiosity and cognitive function. ORA: Organizational religious activity, NORA: non-organizational religious activity, IR: intrinsic beliefs Religiosity, AC: Attention and calculation, VCA: visuospatial constructional ability; MMSE: Mini-Mental Stale Examination; DUREL:Duke University Religion Index; the data in the figure are normalized path coefficients.


As hypothesized, this study found that high religiosity was associated with a reduced risk of MCI, and with the beneficial effects mediated by depression. The mediation effect accounted for 33.03% of the total effect. These findings suggest that religious involvement may be important for maintaining cognitive function over time for Chinese Muslims, which is likely because religion helps them to cope with problems as they get older. These findings are important for understanding how and why religiosity is related to cognitive function.

Compared with those who were less religious, the average depressive symptoms score was significantly higher in those who were more religious. This finding is consistent with a community-based 30-year follow-up longitudinal study in China [18] and a 14 years follow-up study in Canada, which demonstrated that religious involvement reduced the risk of developing major depression by 22% [20]. Furthermore, Paine found that religious involvement predicted lower levels of depressive symptoms in a sample of graduate students in the helping of professions [39,40]. Stimulating activities have been shown to help build cognitive reserve that delays the manifestation of cognitive difficulties [41]. As noted above, religious/spiritual beliefs and activities of older Chinese Muslims may help to buffer against life stress and promote comfort by improving positive psychosocial and physiological coping; In addition, these may increase life purpose and meaning, improve tangible resources from others who are religious, a sense of belonging and empowerment [42]. Similarly, previous research has shown a moderating effect of church attendance on the relationship between depressive symptoms and cognitive function, where higher levels of church attendance appears to have buffered the negative impact of depressive symptoms on cognitive function [21]. Using a structural equation modeling (SEM), David et al found that physical activity influenced cognition directly and reduced depression indirectly by increasing social networks [43]. Much research has shown that depression is a risk factor for cognitive decline, and older people with depression are more likely to have dementia [44-47].

MCI is regarded as a stage of cognitive impairment that is intermediate between normal ageing and dementia, where impairments have not yet affected the individual’s ability to function in daily life [48,49]. The prevalence of MCI in the current study was found to be over 25% in these community-dwelling Muslims aged 55 years or older. This rate is higher than that in the general Chinese population (with a prevalence of 14.5% in aged 55 years and older) [50]. The difference may be explained by several factors. First, the prevalence of MCI was different depending on age, sex, education, marital status, and place of residence. Participants were selected here from a poor economic region. Nearly 83.7% came from rural areas, and 83.1% were involved in peasantlevel occupations. Those sociodemographic characteristics may have influenced the high prevalence of MCI found here [50]. Second, the current study examined the association among religiosity, depression and MCI in a nonrandom community sample. The method of participant enrollment may have caused a select bias, particularly since they were recruited from community health centers.

The findings of current study have several potential implications. Although we are not suggesting that religious activity be prescribed for the people of China, with increasing openness shown by the Chinese government to religious organizations in recent years, our findings may suggest by helping elder Muslims cope with stressors, religious involvements may help them maintaining better cognitive function. We also encourage the depressed elderly patients receive antidepressant treatment as well as faith-based treatment that have well established and showed more efficacious than conventional treatment [51], could help to prevent the loss of cognitive function by reducing depression, thus helping to prevent dementia.


The present study has several limitations. First, the cross-sectional design of this study prevents any statements about the causal direction in the relationships found. Religious involvement could either lead to better cognitive functioning or better cognitive functioning could promote increased religious involvement. Hence, a longitudinal study or clinical trial would be necessary to determine causal relationships. Second, due to the low education level of our sample (57.2% of the total sample were illiterate), cognitive function may have been overestimated producing measurement bias (although education level was adjusted when examining the relationships between religiosity, cognitive impairment, and depression). Furthermore, there potential confounders like economic status and occupation were not included in the statistical models, but which could influence relationships between key variables in this study.


The present study examined the relationship between religiosity, depression, and cognitive function in a large sample of Chinese Muslim elders. Using regression analyses and SEM, we investigated how religious involvement may influence cognitive functioning, finding depression to be a major mediator of this relationship. Religiosity appeared to have significant mediating and direct effects on cognitive function, where religious involvement was found to be important in maintaining cognitive function in these older individuals by reducing the prevalence of depressive symptoms. These findings provided information that may help guide future research and programs designed to further understand and enhance the management of MCI, perhaps through a partnership between public health practitioners and religious organizations.


Funding was provided Open Research Fund for Top Disciplines of Public health and Prevent Medicine at Ningxia Medical University (NXYLXK2017B08). These funding bodies played no role in designing the study, collecting, analyzing or interpreting the data, writing the manuscript, or deciding to submit the paper for publication.

Conflicts of Interest

The authors have no conflicts of interest to report.

Author Contributions

SY and WZ participated in the design of the study, SY, MW, and WY conducted the data collection. SY conducted the statistical analysis and wrote the first draft of the manuscript. MW, HK and WZ oversaw the data analysis, and reviewed the draft manuscript. All the authors have read and approved the final manuscript.


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