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Otorhinolaryngologic Findings in Pediatric Patients with Pandas

Author(s): Salvatore Cocuzza, Silvia Marino, Sung Yoon Cho, Milena Di Luca, Raffaele Falsaperla, Paola Di Mauro, Agostino Serra, Dong-Kyu Jin, Luca Sabino, Piero Pavone

With PANDAS (Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) are defined a spectrum of pathologies with different neuropsychiatric phenotypes related to a current or previous trigger infection favored by group A beta-hemolytic streptococcus (SBEGA). Their main pictures are characterized by acute-onset infantile movement and behavioural diseases in which it can occur the presence of END or other otorhinolaryngologic symptoms.

Built retrospective descriptive study over a multicenter court of 73 patients, the current work is proposed as one of the first attempts to analyze links and relationships with END manifestation and sequent findings in patients with PANDAS. From our analysis comes out that even if respiratory diseases could be present in a subgroup of patients, they are mainly related to hypertrophic or malformation conditions, reason why surgical therapy is still considered a first-line therapy.

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