All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Neural Correlates of Emotional Ambiguity in Patients with Schizophrenia – Relationship with Expressive Deficits

Author(s): Jozarni J Dlabac-de Lange, Leonie Bais, Remco J Renken, Henderikus Knegtering, Edith J Liemburg,André Aleman

Abstract

Objective:  Negative symptoms can be grouped into two factors, expressive deficits and social-emotional withdrawal. We aimed to examine the neural correlates of the two negative symptom factors during a social cognition task, which measures emotional ambiguity in a social context by presenting an array of faces with varying degrees of consistency in emotional expressions.

Methods: Patients with schizophrenia (N=38) and healthy controls (N=20) performed a social cognition task during fMRI that probed both affect and ambiguity. Differences in brain activation between the healthy controls and patients were non-parametrically tested. Subsequently, the expressive deficits and social-emotional withdrawal factors were regressed against task-related brain activation.

Results:  Severity of expressive deficits was negatively correlated with activation of the ventromedial prefrontal cortex when comparing ambiguous emotional decisions to ambiguous gender decisions. During emotional ambiguity, severity of expressive deficits was negatively correlated with activation in thalamic, prefrontal, precentral, parietal and temporal brain areas. No associations between social-emotional withdrawal and brain activation were observed.

Conclusion:  Hypoactivation of the fronto-thalamic circuitry during ambiguous social appraisal may imply a reduced action readiness in social situations, underlying expressive deficits but not social-emotional withdrawal. The findings provide further evidence for different neurobiological bases of the two factors of negative symptoms.


Full-Text | PDF

Share this       

antalya escort

izmir rus escort

bursa escort bayan

antalya escort bayanlar

izmir escort

porno indir

porno izle

mobil porno

eskişehir escort

burdur escort

bartın escort

havalandırma

türk takipçi satın al

smmabi.com

takipbonus.com

izmir escort

bursa escort

türk porno

escort bayan

yabanci porno

takipçi satın al

takipçi satın al

instagram takipçi satın al

instagram beğeni satın al

adana escort

takipçi satın alma

izmir escort

konya escort

instagram takipçi satın al

porno

instagram takipçi satın al

takipçi satın al

spotify takipçi

tiktok takipçi satın al

instagram keşfet satın al

escort feke

takipçi satın al instagram

takipçi instagram satın al

eskişehir bayan escort

bursa escort bayan

smm gerçek panel

etiler escort

soğanlı escort

erenköy escort

maslak escort

küçükyalı escort

ortaköy escort

bostancı escort

taksim escort

çağlayan escort

eyüpsultan escort

kozyatağı escort

nişantaşı escort

anadolu yakası escort

avrupa yakası escort

bahçelievler escort

silivri escort

kadıköy escort

beylikdüzü escort

şile escort

esenler escort

paper io

agario

oversatt

Elektronik Sigara