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MTHFR Gene Polymorphism Positive Treatment-Resistant Depression: Prevalence and Treatment Recommendations

Author(s): Robert P Duprey

Major depressive disorder (MDD) is a treatable mood disorder with an estimated 15.7 million adults aged 18 or older in the United States having at least one major depressive episode in the past year [1]. This number represents a prevalence of 6.7% of all adults in the US population. Ten to 15% of MDD cases can be classified as treatment resistant (TR).

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