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Insomnia in Peri- and Postmenopausal Women: Plasma Lipids, Lipid Peroxidation and Some Antioxidant System Parameters

Author(s): N.V. Semenova, I.M. Madaeva, S.I. Kolesnikov, E.I. Solodova, L.I. Kolesnikova


According to the current data, most menopausal women have reduced quality of life and one of the main criteria is sleep. It is possible, that sleep loss may cause oxidative stress. This study determines sleep disorders characteristics, lipid profile, lipid peroxidation and antioxidant system parameters in peri- and postmenopausal women.


126 menopausal women divided into perimenopausal (n=56) and postmenopausal (n=70) groups were examined. Each group was divided into control (without sleep disorders) and main groups (insomnia and insomnia with obstructive sleep apnea syndrome (OSAS). Pittsburg Sleep Quality Index, Epworth Sleepiness Scale, Insomnia Severity Index, polysomnography were used for the assessment of sleep disorders. Lipid metabolism parameters by the enzymatic method were determined. Lipid peroxidation and antioxidant system parameters (conjugated dienes (CDs), malonyl dialdehyde (MDA), α-tocopherol, retinol, reduced and oxidized glutathione by spectrophotometric and fluorometric methods were determined.


The increase of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were observed in perimenopausal women with insomnia and OSAS. The increase of TC, triacylglycerol (TG), LDL-C, very-low-density lipoprotein cholesterol (VLDL-C) levels and decrease of high-density lipoprotein cholesterol (HDL-С) level were found in postmenopausal women with insomnia and OSAS as compared to control and group with insomnia. Accumulation of lipid peroxidation products was observed both in perimenopausal women with insomnia (CDs) and in postmenopausal women with insomnia (CDs, MDA) and insomnia with OSAS (MDA). There were no differences in antioxidant system parameters between main and control groups.


Both insomnia and insomnia with OSAS are associated with oxidative stress only in postmenopausal women. There are no differences in the accumulation of MDA between insomnia and insomnia with OSAS both in perimenopause and postmenopause.

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