All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Indentification of Novel Biomarkers for Paroxysmal Non- Kinesigenic Dyskinesia Diagnosis Via Cerebrospinal Fluid and Plasma Proteomic Analysis

Author(s): Jianfei Cui, Xiaoman Yu, Shaohui Zhang, Ping Ding, Shuli Liang


Paroxysmal non-kinesigenic dyskinesia (PNKD) is a rare autosomal dominant movement disorder characterized by spontaneous attacks. The purpose of this study was to find and analyze the differentially expressed proteins between PNKD patients and their healthy family members with matched age and gender, thus providing potential biomarkers for early diagnosis of patients with PNKD.


Four PNKD patients and four healthy family members were selected. Isobaric tags for relative and absolute quantitation (iTRAQ) coupled with LC-MS/MS were used to identify the differential proteins obtained from CSF and plasma of PNDK patients and healthy family members. Bioinformatic analyses of differential proteins were performed included Gene Ontology (GO) enrichment, pathway enrichment and protein-protein interaction network analysis.


A total of 1242 and 512 unique proteins were identified in CSF and plasma respectively. The numbers of proteins that were differentially expressed between PNKD patients and their healthy family members were 42 in CSF and 57 in plasma respectively. Proteins that were differentially expressed were further analyzed based on bioinformatics. Two differentially expressed proteins in the CSF, CALML5 and PDGFA, and one in the plasma, ACTB, showed close links with the PNKD protein in the protein–protein interaction network.


CALML5 and PDGFA in the CSF and ACTB in the plasma may take part in PNKD pathogenesis and act as the potential biomarkers for PNKD diagnosis.

Full-Text | PDF

Share this       

antalya escort

izmir rus escort

bursa escort bayan

antalya escort bayanlar

izmir escort

porno indir

porno izle

beşiktaş escort

eskişehir escort

burdur escort

bartın escort


türk takipçi satın al

izmir escort

bursa escort

türk porno

escort bayan

yabanci porno

takipçi satın al

takipçi satın al

instagram takipçi satın al

instagram beğeni satın al

instagram takipçi satın al

takipçi satın alma


panel smm

takipçi satın al instagram

smm panel

ataköy escort

izmit escort