All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Gray Matter Reduction in Currently Depressed Patients of Major Depressive Disorder: A Meta-Analysis

Author(s): Chen Lin, Yun Bian, Xiaole Han, Li Chen, Yu Zhu, Dachun Chen

Aim:

Existing studies have shown that gray matter changes may be involved in the pathophysiology of major depression disorder (MDD). However, whether the severity of the disease can affect the change of gray matter was still controversial. The aim of the present study is to identify the changes of gray matter on patients with currently depressed MDD (cMDD) using metaanalysis based on the reported studies with VBM.

Methods:

A systematic retrieval of PubMed, Web of Science, Embase, Medline, and Science Direct was conducted to identify VBM studies that compared the gray matter differences between MDD patients (untreated or not recovered) and healthy controls. A meta-analysis was then carried out to quantitatively evaluate the gray matter changes of patients with cMDD.

Results:

Seventeen data sets from 14 studies were used in the present meta-analysis. The results showed reduced gray matter in the left superior temporal gyrus, right superior temporal gyrus, right insula, left median network, and left inferior parietal gyrus in patients with cMDD. It was also shown that the percentage of female patients and the mean age did not have a significant relationship with gray matter changes.

Conclusion:

The meta-analysis in the present study showed that the gray matter reduction not only exists in the frontal lobe and the hippocampus of patients with cMDD as reported in previous studies, but also exists in the temporal lobe, which may also be important in the pathophysiology basis of MDD.


Full-Text | PDF

Share this       

antalya escort

izmir rus escort

bursa escort bayan

antalya escort bayanlar

izmir escort

porno indir

porno izle

mobil porno

eskişehir escort

burdur escort

bartın escort

havalandırma

türk takipçi satın al

smmabi.com

takipbonus.com

izmir escort

bursa escort

türk porno

escort bayan

yabanci porno

takipçi satın al

takipçi satın al

instagram takipçi satın al

instagram beğeni satın al

instagram takipçi kazan

takipçi satın al

instagram takipçi satın al

smm panel

instagram takipçi satın al

takipçi satın al

takipçi satın al

takipçi satın al

takipçi satın al

instagram takipçi hilesi

tiktok takipçi hilesi

türk takipçi satın al

takipçi satın al spotify

tiktok takipçi satın alma

ucuz takipçi satın al

tiktok takipçi satın al

instagram unfollow

paper io

agario

oversatt

Elektronik Sigara