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Gray matter alterations in cirrhosis with and without hepatic encephalopathy: a meta-analysis of voxel-based morphometry studies

Author(s): Yu-Chen Chen, Wenqing Xia, Yuan Feng, Jun Ren, Xindao Yin, Jian-Ping Gu

Voxel-based morphometry (VBM) studies have revealed brain gray matter (GM) abnormalities in cirrhotic patients with and without hepatic encephalopathy. However, these findings are heterogeneous and have not been quantitatively reviewed. Here, we aimed to conduct a meta-analysis that integrated the existing VBM studies, to determine concordant GM alterations in patients with cirrhosis. A systematic search was conducted for the whole-brain VBM studies comparing cirrhotic patients with healthy controls. Coordinates were extracted from clusters with significant GM differences.

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