Different Patterns of Glucose Hypometabolism Underlie Functional Decline in Frontotemporal Dementia and Alzheimer’s Disease: FDG-PET StudyAuthor(s): Mina Fukai, Tetsu Hirosawa, Mitsuru Kikuchi, Shoryoku Hino, Tatsuru Kitamura, Yasuomi Ouchi, Masamichi Yokokura, Etsuji Yoshikawa, Tomoyasu Bunai, Yoshio Minabe
Objective: Functional decline in daily life is a common difficulty among patients with dementia. Nevertheless, little is known about the neural correlates of functional decline. We hypothesized that functional impairment is associated with metabolic abnormalities in distinct regions in cases of Alzheimer’s disease (AD) and frontotemporal dementia (FTD).
Methods: After 49 patients with AD, 13 patients with FTD, and 21 normal participants underwent a [18F] fluorodeoxyglucose (FDG)-positron emission tomography scan, we evaluated the relations between functional decline measured using Functional Assessment Staging (FAST) and regional cerebral glucose metabolism from voxel-based analyses.