All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Comparison of pre-treatment clinical characteristics and post-treatment outcomes of patients treated with Clozapine and long acting antipsychotics

Author(s): Dante M Durand, Phillip Harvey, Ricardo Caceda

Introduction:

Clozapine is a cornerstone in the treatment of resistance schizophrenia, whereas long-acting antipsychotics (LAA) are central in the care of patients with poor compliance. Both populations represent daunting challenges. We aim to compare pre-treatment disease severity and treatment outcome of patients receiving clozapine and LAA.

Methods:

Medical records of patients who attend an outpatient schizophrenia clinic were randomized and examined retrospectively. Demographics and psychiatric history prior hospitalizations and suicide attempts were reviewed. Additionally, the Positive and Negative Symptom Scale (PANSS) and Medication Adherence Rating Scale (MARS) were administered to patients during their last visit.

Results:

Preliminary results from 27 patients show that those on LAA had more hospitalizations (p=0.021) and suicide attempts (75% vs. 11%, p=0.034) than patients on clozapine before initiation of treatment. There were no differences in frequency of visits, MARS or PANSS scores between the two groups. Negative symptoms were more predominant among the patients on long-acting antipsychotics than in those on clozapine, although the difference was borderline significant.

Discussion:

Patients on LAA had a more severe disease course prior to the initiation of LAA, reflected in more hospitalizations and suicide attempts, possibly due to persistent non-compliance with oral treatment in the past. Patients on clozapine had more recent hospitalizations, perhaps due to suboptimal dosing. Treatment adherence and symptom burden were similar in both patient groups. There was an expected trend of patients on long acting antipsychotics to display poorer negative symptom control than those on clozapine.


Full-Text | PDF

Share this       

antalya escort

izmir rus escort

bursa escort bayan

antalya escort bayanlar

izmir escort

porno indir

porno izle

mobil porno

eskişehir escort

burdur escort

bartın escort

havalandırma

türk takipçi satın al

smmabi.com

takipbonus.com

izmir escort

bursa escort

türk porno

escort bayan

yabanci porno

takipçi satın al

takipçi satın al

instagram takipçi satın al

instagram beğeni satın al

adana escort

takipçi satın alma

izmir escort

konya escort

instagram takipçi satın al

porno

instagram takipçi satın al

takipçi satın al

spotify takipçi

tiktok takipçi satın al

instagram keşfet satın al

escort feke

takipçi satın al instagram

takipçi instagram satın al

eskişehir bayan escort

bursa escort bayan

smm gerçek panel

etiler escort

soğanlı escort

erenköy escort

maslak escort

küçükyalı escort

ortaköy escort

bostancı escort

taksim escort

çağlayan escort

eyüpsultan escort

kozyatağı escort

nişantaşı escort

anadolu yakası escort

avrupa yakası escort

bahçelievler escort

silivri escort

kadıköy escort

beylikdüzü escort

şile escort

esenler escort

paper io

agario

oversatt

Elektronik Sigara