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Clinical Factors Associated with Fatigue in Parkinsons Disease

Author(s): Chao Tung Chen, Kuei-Yueh Cheng, Wen-Neng Chang, Nai-Wen Tsai, Chih-Cheng Huang, Chia-Te Kung, Wei- Che Lin, Hung-Chen Wang, Yu-Jih Su, Ben-Chung Cheng, Ya-Ting Chang, Chih-Min Su, Sheng-Yuan Hsiao, Cheng-Hsien Lu


Fatigue is one of the common non-motor symptoms in patients with Parkinson’s disease (PD). This study aimed to explore the associated clinical factors on fatigue in PD.


This prospective study enrolled 141 adult idiopathic PD patients. Fatigue were classified in accordance with Fatigue Severity Scale (FSS) with a threshold of means score ≥5.


Fatigue occurred in 66 (66/141, 46.8%) patients. FSS total score is positively correlated with age, diseases duration, levodopa equivalent dose (mg), Unified Parkinson’s Disease Rating Scale (UPDRS) I, UPDRS II, UPDRS III, total UPDRS, and Geriatric Depression Scale but negatively correlated with education years, striatal dopamine transporter uptake ratios, and Mini-Mental State Examination. Total mean UPDRS score remained independently associated with the presence of fatigue. Any increase one point in mean URDRS score one point will increase 6.2% of presence of fatigue rate. The area under the ROC curve for the mean URDRS score was 0.859 and the cut-off value to predict presence of fatigue was 41.5


Higher mean URDRS score (>41.5), which may imply an increase in the severity of PD, was associated with higher risk of fatigue. Preventing fatigue and develop developing therapeutic strategies in the high-risk PD group is an important safety issue and highly relevant for their quality of life.

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