All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Associations between Serum Brain-Derived Neurotrophic Factors and Bipolar Disorder

Author(s): Yi-Shan Wu, Yu-Jie Chiou, Tiao-Lai Huang


Background: Brain-derived neurotrophic factor (BDNF) is known related to the psychopathology of bipolar disorder. However, the results of the relationship between BDNF levels and bipolar disorder were inconsistent. In this study, we aimed to investigate the relationship between BDNF levels, the different phases and clinical phenotypes of bipolar disorder.

Methods: Over a 4-year period, bipolar patients in different disease phases, including mania phase, depressive phase and remission, were recruited. All participants had peripheral blood drawn to analyze the serum BDNF levels. We also investigated the relationships between serum BDNF levels, violence, suicidal behavior and Young Mania Rating Scale score (YMRS) before and after 4-week treatment.

Results: A total of 102 participants in different disease phases, including acute mania (n=44), acute depressive episode (n=20) and remission (n=38) of bipolar disorder were invited for this study. The serum BDNF levels of patients with acute mania or depressive phases were significantly lower than bipolar patients in remission phases using ANCOVAs with age and sex adjustment (mania: p=0.013, depression: p=0.003, respectively). Bipolar mania patients with violence had lower BDNF levels than those without violence (p=0.025). Among 42 followedup patients, increased BDNF level from baseline was noted after one-month treatment, but there is not statistically significant by means of paired t test (mania: p=0.845 and depression: p=0.931, respectively).

Conclusions: Our study found that lower serum BDNF levels are strongly associated with the depressive and manic phase of bipolar disorder than remission phase. In addition, bipolar mania patients with violence had lower BDNF levels than those without violence. In the future, it needs a large sample to prove these results.

Full-Text | PDF

Share this       

antalya escort

izmir rus escort

bursa escort bayan

antalya escort bayanlar

izmir escort

porno indir

porno izle

beşiktaş escort

eskişehir escort

burdur escort

bartın escort


türk takipçi satın al

izmir escort

bursa escort

türk porno

escort bayan

yabanci porno

takipçi satın al

takipçi satın al

instagram takipçi satın al

instagram beğeni satın al

instagram takipçi satın al

takipçi satın alma


panel smm

takipçi satın al instagram

smm panel

ataköy escort

izmit escort

Ledger Live desktop: Your secure gateway to crypto. Secure your assets with confidence using Ledger Live desktop. Experience a secure gateway that prioritizes the safety of your digital assets, providing peace of mind.