Abstract

Anatomical faces of neuroprogression in bipolar disorder

Author(s): Bianca Pfaffenseller, Clarissa Severino Gama, Flavio Kapczinski, Juliana Avila Duarte,Mauricio Kunz

These two MRI images illustrate the anatomical changes associated with the progression of illness in bipolar disorder (BD). There is significant cortical atrophy and enlargement of ventricles in a patient with a history of multiple mood episodes (B) compared with a patient of the same gender and similar age that only experienced a few episodes and a shorter length of illness (A).