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A Survivor of a Motor Vehicle Accident with Depression and Cognitive Impairment a Case of Probable Creutzfeldt - Jakob disease

Author(s): Mason Chacko 1,2,*, JeissonFontecha-Hernandez1, Jessica Carbajal1, Robert Peyeser1, Ricardo C?????????????????????íceda1,3

Introduction: Creutzfeldt-Jakob disease (CJD) is a lethal prion disease which can present with a variety of neurological or psychiatric presentations. Even though the outcome is eventually lethal, CJD can be unrecognized and confuse prognosis and management. Case Presentation: We present a case of a 65-year old female with history of depression and anxiety who presented following a motor vehicle accident, confused, tongue deviation, vertical nystagmus, and with history of progressive lapses in memory. After initial work up, she was diagnosed with probable CJD based on cortical ribboning in diffusion weighted imaging magnetic resonance imaging, a positive cerebrospinal fluid 14-3-3 protein and vertical nystagmus supported the diagnosis of probable CJD. Conclusions: We add to the nascent literature by presenting a case of probable CJD with an initial atypical presentation of depression, anxiety and memory impairments. 

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