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Abstract

Neurological presentations and therapeutic responses to cobalamin deficiency

Author(s): Min-Chien Tu, Chung-Ping Lo, Ching-Feng Huang, Yen-Hsuan Hsu, Tzu-Lan Wang

The clinical phenotypes of cobalamin (Cbl) deficiency is often overlooked in clinical practice as their presentations vary according to the level of involvement between the hematologic and nervous systems. Although the negative impact of Cbl deficiency on cognition has been underpinned, the reported therapeutic responses after Cbl supplement therapy differ. Therefore, we aimed to describe the neurological presentations of patients with Cbl deficiency and investigate the potential biomarkers in predicting therapeutic responses with emphasis on cognitive aspects.


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