Reach Us +18507546199
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Case Report - (2019) Volume 9, Issue 1

Landau Kleffner Syndrome: An Unusual Case With Progressive Ataxia Prior To Language Regression And Autistic-Like Behaviors

Corresponding Author:
Dr. Wen-Xiong Chen
Department of Neurology, Brain Center, Guangzhou Women and Children’s Medical Center Guangzhou Medical University, 9# Jin Sui Road, 510623, Guangzhou City, Guangdong Province P.R. of China
Tel: 86-020-38076127

Abstract

Objective

To report a case with Landau-Kleffner syndrome (LKS) presenting with unusual clinical features.

Methods

The clinical features of the case including clinical manifestations, serial electroencephalography (EEG) outcomes, neuroimaging findings, neuropsychological outcomes, interventional approaches and long-term follow-up outcomes, were analyzed.

Results

This previously normal girl (3y10m), presented with progressive ataxia as an onset symptom, ensued with cognitive impairments and language regressions (characterized by verbal auditory agnosia and expressive aphasia), and autistic-like behaviors. She had no evidence of clinical seizures, with normal brain and spine MRI scans, intact auditory exams and normal brain auditory evoked potential, although the sleep- activated inter-ictal epileptiform discharges of EEG were revealed. The patient showed gradual resolution of symptoms with long-term high-dose steroids plus intravenous immunoglobulin (IVIG) regimens, in consistence with the gradual improvement of the outcomes of serial EEGs. She recovered and returned to normal kindergarten 1y1m after the onset of the disease, consistent with the normal EEG results. Her full-scale intelligence quotient (IQ) was 71 score, with verbal IQ 66 and performance IQ 81 respectively, tested at the time of 1y3m after the onset. The long-term prognosis of the case was good as she had good academic performance and was a monitor of the class at the time of her long-term follow-up of 5y8m after the onset.

Conclusion

LKS is heterogeneity entity, especially for those with the atypical onset such as ataxia, as well as absence of clinical seizures. The combination of long-term high-dose steroid plus IVIG regimens may be especially effective in LKS.

Keywords

Landau-Kleffner syndrome (LKS), Ataxia, Language regressions, Autistic-like behaviors, Cognitive impairments, Steroid

Introduction

Landau–Kleffner syndrome (LKS) or acquired epileptic aphasia, first described by Landau and kleffler in 1957 [1], is a rare childhood neurological disorder, being characterized by an acquired aphasia that emerges in relation to epileptiform electroencephalographic (EEG) abnormalities [1,2].

The most prominent defining feature of Landau- Kleffner syndrome is an acquired aphasia [2], whereas epileptic seizures are not a prerequisite for LKS. The typical type of aphasia is a verbal auditory agnosia, failure to provide a semantic significance to the different sounds. The loss of receptive language is followed or simultaneously occurred by expressive aphasia, a marked reduction in spontaneous speech. Other clinical manifestations include cognitive impairments and behavioral problems. These impairments may be global or focal, based on the location of the epileptic discharges, and progressive, presumably related to increasing epileptiform activity.

LKS is a heterogeneous entity, with rather significant variations in terms of age of onset, the aphasia’s characteristics, EEG abnormalities, and comorbid cognitive and behavioral impairments [3], leading to the challenges of diagnosis. We reported an unusual LKS girl presenting with atypical onset prior to typical manifestations, and her long-term follow-up outcomes.

Case report

A previous healthy girl with LKS was reported, who was the 2nd child of the three children’ family, a full-term baby (birth weight: 3.35 kg) via virginal sections following a normal 40 weeks pregnancy with unremarkable events and did not require support services after birth. The child’s early developmental milestones achieved all the developmental domains including expressive and receptive language at the appropriate time with the babbling at 8 month, first word at 11 month, combining words available at the age of 2 years, when she generated sentences of 3 and 4 words with a good verbal comprehension. There was no other pertinent medical history before age 3 years and 10 months (3y10m). She had no known family history of epilepsy and other neurological disorders. Her older sister and younger brother did not have the same disorders as the girl had.

The age of onset was 3y10m, presenting with progressive ataxia prior to cognitive impairments and language regressions, and autistic-like behaviors. The clinical features of the case including clinical manifestations, neurological examinations, clinical investigations and treatments were summarized in the Table 1. The research protocol was approved by the Institutional Review Board of the Guangzhou Women and Children’s Medical Center. Written informed consent was obtained from the parents.

Phases/Date of visit
/Visiting methods
Clinical manifestations Neurological
examinations
Main clinical investigations Treatments
A/26-11-2012~12-12-20 12/Hospitalization at local tertiary medical college affiliated hospital (after 2 days of onset). 1.Progressive ataxia without precipitating factors at the age of onset 3y10m; 2. The unusual posture when up and down stairs as the symptom of onset noted by parent; 3. Followed by the abnormal gait with wide-base, walking unsteadily and easily falling
down.
NE at admission: Normal except cerebellar signs with wise-base gait and truncal ataxia. CSF: Normal; Bilateral calcaneus, lumbar and pelvic x ray: Normal; 3.1~hour VEEG: Sleep-activity bilateral central-temporal IEDs without clinical events;
4. Brain CT/MRI and Spine MRI (Scan): Normal.
Progressive cerebellar ataxia was diagnosed. Treated with 4~day (0.5 g/kg/d) IVIG + 3~day high dose (20 mg/kg/d) MPN, followed by 4~day IV Dex (0.25 mg/kg/d). A slight improvement on sitting posture after treatment.
B/12-12-2012~21-12-20 12/Hospitalization at GZWCMC. During hospitalization:
1. Markedly improved in the walking posture after treatment with just left slightly unstable walking posture at discharge; 2. The status of restlessness or agitation noted sometimes.
NE at admission: Normal except walking unsteadily with wide-base gait. Repeated CSF: Normal; 1~hour VEEG: Normal; Repeated brain MRI (Scan + Contrast): Normal Oral prednisone (1 mg/kg/d) was continued.
C/08-01-2013/Outpatien t at GZWCMC. Ataxia was complete recovery; Somewhat less desires to communicate with others and less lively during daily life noted by parent. NE at outpatient: Walking posture normal, but less communicated
with doctor.
Nil Oral prednisone was tapered off after a total
1.75 months course of steroid.
D/08-01-2013~04-03-20 13/ At home. 1. Verbal auditory agnosia: Did not understand what parents’ or grandmother’s said, e.g. asking her to call grandmother, she went to get a broom instead. 2. Expressive aphasia: Almost simultaneously, spontaneous speech gradually reduced with paraphasias and impairments in fluency and articulation, and even mutism sometimes. 3. Autistic-like behaviors: Including hyperactive, irritable, impulsivity, just did or played something she liked, stayed alone, no response to name call, although sometimes could take telephone up when ringing. 4. Others: Intelligence, memory and learning
abilities backward noted by parent.
Nil Nil Nil
E/04-03-2013~21-03-20 13/Hospitalization at GZWCMC. During hospitalization:
1. Some abnormal behaviors: occupied the bench, stereotyped behaviors (e.g. repeatedly touched her
NE at admission: Normal except less spontaneous
speech with
1.Repeated brain MRI (Scan + Contrast) and MRA: Normal; 2. Auditory exam and BAEP:
Normal;
The suspected LKS was made; Repeated 5~day course (0.4 g /kg/d) IVIG. Parent hesitated to
  toes), and weird behaviors (e.g. went to other wards to get the high-heeled shoes). 2. A little bit improved in communication, and a slightly more vocalizations and more frequencies of
laughs after IVIG treatment.
Dysarthria and non-meaningful vocalizations; reluctant to communicate
with others.
3. Two 1~hour VEEGs tested at the interval of 7 days, with the nearly similar outcomes: Sleep-activity bilateral frontal-temporal IEDs without
clinical events.
accept the long-term high-dose steroid regimen or AEDs for her daughter, instead choosing to discharge for further observation the changes of her daughter at home.
F/21-03-2103~10-04-20
13/At home.
1. Some abnormal behaviors:Hyperactivity, irritability,easily temper tantrum, compulsive behaviors (insisting on grandmother should company with her every night when sleep),stereotype behaviors
(repeatedly play her own toes, liked to sit on the ground and repeatedly moved back and fro), picking something on the ground into mouth.
2. Unlike to actively communicate with others and less spontaneous speech with dysarthria sometimes. 3.Liked to rummage through others’
belongings.
Nil Nil Nil
G/10-04-2013~25-04-20
13/Hospitalization at
GZWCMC.
During hospitalization:
1. After initial 3~day course MPN
given, eye-contact showed a little bit
better. 2. The frequencies of
eye-contact better and temper tantrum
less, after 8~day course MPN
treatment. 3. At discharge, she could
even erect her thumb as a “praise
symbol”; more vocalizations, although
only with “Yo, Yo” sounds; more
positive attitudes about circumstances.
NE at admission:
Spontaneous
language less
with dysarthria;
unwilling to
answer.
1~hour VEEG: Sleep-activity left
side frontal-temporal IEDs
without clinical events.
The long-term high-dose steroid treatment regimen given. The dose of MPN was gradually tapered from 10-5-2.5-1.25 mg/kg/d at the 3 days interval, and changed into the oral prednisone (1.5mg/kg/d) at discharge.
H/08-05-2013~14-05-20 13/Hospitalization at
GZWCMC.
1. At home (25-04-2017~08-05-2017): Behavior disturbances getting better,
e.g. controlling emotions better; no longer taking others’ things; could
even happily say “grandmother” when
returned home after discharge last
time, although no more spontaneous
words thereafter; a couple of times,
could even eat rice by herself. 2.
During hospitalization: Behaviors
getting more organized; more
utterance of “Yo, Yo” sounds; could eat between-meal nibbles by herself, although still need to be fed by mother three meals a day; sometimes still liked to clap her palms purposelessly.
NE at admission: Could actively
laugh at doctor with “Yo, Yo”
sounds, and even
could response
and give her toy
to doctor when
asked, although
clapping her
palms purposelessly sometimes.
1~hour VEEG: Sleep-activity left side frontal IEDs without clinical
events.
1. Repeated 5~day course of IVIG (400 mg/kg/d).
2. Oral prednisone (1.5mg/kg/d) continued.
I/29-05-2013~01-06-201 3/Hospitalization at
GZWCMC.
1. At home (14-05-2013~29-05-2013): Better controlling her emotions; could
follow some instructions. 2. During
hospitalization: Said simple words;
could understand instructions sometimes; unwilling to answer
sometimes.
NE at admission: Could answer
simple questions;
even could recite
whole Chinese
poem “goose”
when asked.
1~hour VEEG: Sleep-activity left side frontal IEDs without
clinical events.
1. Oral prednisone (1.0mg/kg/d) continued.
J/29-07-2013~01-08-20 13/Hospitalization at
GZWCMC
(after 8 months of onset).
1. At home (01-06-2013~29-07-2013): Language ability and behavior
disturbances markedly improved with
almost returned to normal level; could
eat by self; played with other children;
picked someone she liked. 2. During
hospitalization: Spoke freely, and
acted according to instructions.
NE at admission: Could take and
show a toy to doctor and say
“garden baby”;
Corporation during NE.
1~hour VEEG: Normal. 1. The diagnosis made. Of confirmative LKS was
2. Oral prednisone (0.5mg/kg/d) continued.
K/28-08-2013/Outpatien t at GZWCMC. At home (01-08-2013~28-08-2013): Uneventful with eager to go to school. NE at outpatient: Saw doctor with
smile.
Nil Oral prednisone (0.5mg/kg/d) continued.
L/25-09-2013/Outpatien t at GZWCMC. At home (28-08-2013~25-09-2013):
Uneventful with eager to go to school; liked to played with other children
Saw doctor with
smile; answered accordingly.
Nil Oral prednisone (0.25mg/kg/d) continued.
M/23-10-2013/Outpatie nt at GZWCMC. At home (25-09-2013~23-10-2013):
Returned to normal child’s situation with eager to go to school, and loved to play with other children.
Happily laughed when knew she
could return to
kindergarten.
1~hour VEEG: Normal Oral prednisone 0.125 mg/kg/d) continued.
N/27-12-2013/Outpatien t at GZWCMC (1y1m
after onset).
At home (23-10-2013~27-12-2013):
Returned to normal kindergarten as a student; having a desire to excel.
At outpatient:
In response to the point when asked.
Nil Prednisone tapered off
O/03-03-2014/outpatient at GZWCMC (1y3m
after onset).
Uneventful at home and school. At outpatient:
In response to the point when asked.
WSIC-IV:FIQ:71;PIQ: 81; VIQ:66. Nil
P/26-07-2017/Telephone
follow-up (after 4y8m of
onset)
PG 1 student and served as a class
Monitor (Teacher’s comment: enthusiastic, kind and responsible)
with good academic performance such
as Chinese 98.5 and Math 100 at final
exam of the semester.
Nil Nil Nil
Q/26-08-2018/Telephon e follow-up (5y8m after
onset)
PG 2 student and served as a class monitor with good academic
performances.
Nil Nil Nil

Table 1. The clinical process of the case

Discussion

Landau-Kleffner syndrome (LKS) is a rare childhood epileptic encephalopathy, along with a deterioration of cognitive, sensory, and/or motor functions results from epileptic activity [4]. One Japanese study has reported that the incidence of children with LKS aged 514 years was around 1 in a million in Japan [5].

▪ LKS and onset

Age of onset: LKS commonly occurs between the ages of 3 and 7 years based on the ICD-10 guidelines, although onset as early as 18~22 months and as late as 13~14 years has also been stated. The mean age of onset of aphasia was 4.8 years with standard deviation 2.2 years was revealed, according to the analysis of 268 out of 337 LKS cases from the published English literatures [3]. Of which, the most cases (around 90%) presenting their onset was between the ages of 2 and 7 years old and approximately one third of these cases regressed before their 4 years old [3]. The age of onset of the case in our study was 3 years and 10 months, like most reported other cases before their fourth birthday, although she had an unusual neurological symptom’s onset.

Symptom of onset: The onset of LKS may be insidious or sudden. One study reported that the language deterioration was the onset symptom found in the most cases [6], whereas other studies have stated that the epileptic seizures being the initial symptoms more often than the language disturbances [7]. In some rare cases, the parents claimed that they in fact gradually lost contact with their pediatric subjects, which might be attributed to the psychogenic regression [8].

In the current study, a previously normal girl with an onset of progressive ataxia without obvious precipitating factors at around 2-months prior to cognitive impairments and language regressions, and behavioral disturbances was reported. One Japanese study [9] had ever reported one case whose symptom of onset somewhat similar to our case, having ataxia before language regressions, along with hemiparesis, urinary incontinence and convulsions at the age of 4 years and 10 months, followed by acquired aphasia a year later.

▪ LKS and EEG findings/seizures

Despite the severe electroencephalographic abnormalities, seizures never occur in the 20– 30% of LKS patients [10]. The types of the seizures reported in the LKS can be different, including partial complex, partial clonic, generalized tonic-clonic, and atonic seizures [3,11], although absence of clinical seizures was found in our case through the course.

No single epileptiform abnormality could consist of all cases of LKS [12]. The electroencephalographic manifestations of the epileptiform disorder included generalized, bilateral, focal or multifocal, spike or spike-wave discharges (1~3 Hz), usually with a central or temporal lobe predominance [13]. The abnormalities were frequently activated by sleep, particularly at sleep onset [13] and during slow wave sleep. The pattern of continuous spikes and waves during slow sleep (CSWS) or electrical status epilepticus in sleep (ESES) in patients with LKS tends to be unilateral or clearly lateralized. The presence of CSWS/ESES in LKS appears to relate to the continuation of language impairments, and if lasting more than 3 years may be associated with the long-term language deficits [14].

The presence of CSWS/ESES is not a prerequisite for a diagnosis of LKS. In one case series of 25 LKS patients, the CSWS pattern was found in only 9 patients [15]. Another study [16] reported three children whose sleep EEG with normal outcomes after several months of the onset of language regression, although a final diagnosis of LKS was confirmed when subsequent sleep EEG showed interictal epileptiform discharges (IEDs). Similarly, our case did not demonstrate the CSWS/ESES, instead consistent with sleepactivated IEDs.

The symptoms of the case in our study were related to the severity of the epileptiform activity. For instance, the consistent changes of sleepactivated bilateral frontal, central and temporal IEDs (1-3 Hz) were found before steroid plus IVIG treatment (Table 1: A). Subsequently, the improvements of ataxia associated with the normal EEG after the 1st steroid plus treatment (Table 1: B); the gradual ameliorations of autistic-like behaviors as well as language ability either on auditory or on expressive after the 2nd long-term high dose steroid plus treatment, in accordance with the gradual improvements of serial EEG outcomes e.g. from bilateral IEDs (Table 1: E) to unilateral IEDs (Table 1: G, H, I), and final normal EEG (Table 1: J, M).

▪ LKS and language regressions

The language loss is characterized by a severe disturbance of auditory language comprehension and combined with a substantial disruption of expressive language [3]. Children may fail to orient to their name being called or comprehend orally presented information that they could previously attend to and understand without difficulty. Similarly, current case who did not understand what parents or grandmother’s said, e.g. asking her to call grandmother, she went to get a broom instead (Table 1: D), although the outcomes of auditory exams and brainstem auditory evoked potentials were normal . Similarly, one study included 29 LKS patients reported all had moderate to severe auditory verbal agnosia [10].

Basically, the receptive language difficulties were accompanied or closely followed by reductions and distortions of verbal output. Speech became “garbled” and dysfluent, marked by articulatory errors, word-finding difficulties, and declines in the frequency, length, and complexity of verbal utterances [3]. Likewise, our case occurred both in the verbal auditory agnosia and expressive aphasia simultaneously, gradually developed just only with “Yo Yo” jargon, although being mutism at times (Table 1: D).

▪ LKS and behavioral disturbances/ cognitive impairments

About two thirds of children with LKS emerge behavioral disturbances. The most frequently observed behavioral problems are attentional deficits, impulsivity, distractibility, and hyperactivity; others consisted of aggression, anger with tantrums, withdrawal, social deficits, and sometimes autistic-like behaviors such as avoidance and withdrawal, resistance to change in daily activity, gestural stereotypes, echolalia and echopraxia, hyperlexia, or psychotic-like presentations [3,17].

Nonlinguistic cognitive functions were affected in approximately half of the patients [18]. A subtle behavioral or cognitive manifestation of epilepsy can be defined as follows with the two ways [19]. First, epileptiform discharges not presenting as obvious seizures may nevertheless affect cognition and/or behavior. Second, the actual seizures may be obvious but the way they affect cognition or behavior may not be. These impairments may be global or focal, depending on the location of the epileptic discharges, and progressive, presumably related to increasing epileptiform activity. Studies demonstrated that interictal epileptiform activity could disrupt cognition. Similarly, our case existed cognitive dysfunction, such as memory decline and learning disorder, as well as behavioral disturbances such as autistic like behaviors (Table 1), which was related to sleep-activity IEDs of EEG. In LKS, the autistic features can be the results of the epilepsy itself [20].

A retrospective study of 14 LKS children [21] has revealed that the 57% cases evidenced attentional or other behavioral problems, 50~57% having deficits in auditory working memory and verbal memory. Academically, the majority had poor reading fluency and comprehension, and 50% exhibited difficulty with mathematics. The global intellectual functioning ranged from 59 to 101. As a contrast, the full scale IQ of our case was 71 tested at the time after her returning to kindergarten, although the verbal IQ was still lower than that of performance IQ (Table 1: O).

▪ LKS and etiology

The etiology of LKS is still unknown [22], but involvement of the frontal and/or temporal lobes is frequently stated [23]. It is unclear whether LKS represents the late manifestation of preexisting anomalies in neurodevelopment or the result of acquired pathogenetic influences such as an abnormal autoimmune response or both. Like our case (Table 1), the most effective treatment has been used with long-term cortico-therapy in high doses, which supporting possibilities the presumption that the participation of autoimmune factors in the origin of LKS. Recently, the striking finding of mutations in the N-methyl-D-aspartate (NMDA) receptor subunit gene GRIN2A as the first monogenic cause in up to 20% of patients with epilepsyaphasia spectrum including LKS suggests that excitatory glutamate receptors play a key role in these disorders [24,25], although our case didn’t carry out genetic research.

MRI scans are normal in most LKS cases, but PET and SPECT studies have showed focal or multifocal changes or perfusion asymmetries predominantly affecting, but not restricted to the temporal regions [26]. Functional MRI study [27] suggested intact temporal lobe processing but an altered temporal to frontal connectivity.

▪ LKS and diagnosis

The symptoms of LKS are heterogeneous, and these symptoms can lead to misdiagnosis, which makes the EEG examination as an important determinant in the differential diagnosis. One national study found that the parents of children with LKS often struggled with the local health authorities to obtain the correct diagnosis and adequate help [6].

A delay between initial symptoms and definitive diagnosis is not unusual in rare diseases. Sometimes, rarely also the mild neurological symptomatology can be seen as accompanying signs of the disease. Likewise, our case not only developed atypical initial neurological symptoms of ataxia, but also did not experience epileptic seizures; secondly the EEG pattern did not demonstrate CSWS/ESES, instead with IEDs; thirdly, the initial symptoms of behavioral problems and language regression developed insidiously. For instance, the status of restlessness or agitation occurred only sometimes during hospitalization (Table 1: B) or somewhat less desire to communicate with others at outpatient clinic (Table 1: C) at that time when the symptom of ataxia was recovery; Furthermore, there were no family history of seizures of this case. Taken the above evidences together, causing the challenges to diagnose of LKS for the case. Specifically, initial diagnosis of progressive cerebellar ataxia (Table 1: A), ensued the suspected LKS (behavioral problems and language regressions and cognitive impairments, plus sleep-activated IEDs), followed confirmative LKS diagnosis (constellation of clinical findings plus the severity of symptoms in accordance with the changes of serial EEGs outcomes) (Table 1).

▪ LKS and Treatment

In view of the relationship between the occurrence of CSWS/ESES and the language deterioration, early and aggressive therapy is mandatory [10]. Early effective treatment may reverse some of these features [28]. Clinical practice suggests that amelioration in neuropsychological functioning may be related to control of ongoing epileptiform activity in LKS. Several antiepileptic drugs (AEDs), such as valproate, ethosuximide, clonazepam, or clobazam have been demonstrated to be effective.

However, standard antiepileptic drugs often control the clinical seizure activity but may not improve the neuropsychologic dysfunction in LKS. Steroids seem to have more longlasting effects. Early diagnosis, before mutism or global deterioration develops, appears to be esential for effective therapy with minimal neuropsychological sequelae [29]. The series including 44 patients treated with hydrocortisone starting at 5 mg/kg/day with a maintenance dose of 2 mg/kg/day until the end of a full year of treatment [30]. More than 75% of the patients responded to this regimen within the first 3 months, with normalization of the EEG in about half of them. Although relapse occurred in 14 patients, 20 patients (45.4%) were long-term responders. As a contrast, our steroids long-term high-dose regimen treated with methylprednisolone beginning at 10 mg/ kg/days with a maintenance dose of 1mg / kg/day of prednisone until the end of a 7.5 months of treatment plus the intermittent infusions of intravenous immunoglobulin (IVIG) (Table 1: G~M). In terms of novel treatments, adrenocorticotropic hormone is currently preferred due to its clinical and electroencephalographic efficacy.

Amongst the other therapeutic approaches, the benefits of IVIG were not confirmed in a recent series [31], although the promising result in some cases has also been reported. Data on the use of vagus nerve stimulation and ketogenic diet were too scarce to draw conclusions [32,33]. In addition, surgery using multiple subpial transections can be considered in the refractory cases, although negative outcomes were also argued [34].

▪ LKS and prognosis

The long-term outcome of LKS is not completely clear. The outcome of the disease is variable, and serious disturbances of language remain sometimes until adulthood [35]. In addition, the course of recovery in LKS is also comparatively slow or limited. Likewise, our case returned to normal school 1y1m after onset (Table 1: N).

Some studies indicated that whether the aphasia onset occurred before or after 5 years of age had an important impact on long-term outcome [36], but other studies did not confirm this prospective [7]. Our case had relatively good long-term outcomes, although whose onset age was before age 5 (Table 1: A). Nevertheless, long-term language and language-related difficulties may also occur with later onset [7]. One study [6] found that children who had experienced a short initial aphasic period and marked fluctuations in speech ability had the best prognosis with respect to future language outcome.

Patients with LKS had an overall poor quality of life [7], the prognosis of LKS is known to be difficult to predict and uncertain since speech deficiencies typically persist [36]. Fortunately, the long-term prognosis of the case in our study was good as she had a good academic performances, as well as served as monitor of the class 5y8m after the onset (Table 1: P & Q), although she did not repeat IQ test.

Conclusion

LKS is heterogeneity entity, especially for those with the atypical onset such as ataxia, as well as absence of clinical seizures. The combination of long-term high-dose steroid plus IVIG regimens may be especially effective in LKS.

Funding Source

This research is supported by the grants of Science and Technology Department of Guangdong Province of China (2013B021800046 & 2016A020215019) and Doctoral Fund of Guangzhou Women and Children’s Medical Center (5001-2170057), and partly supported by the key projects fund of Ministry of science and technology of China (2016YFC1306200).

Conflict of Interest

There are no conflicts of interest for all authors in this study.

Author Contributions

CWX conceptualized and drafted the study. CWX, YSD, GYY, ZYN and ZKL clinically treated and long-term assessed the subject. NSY, ZYY, PBW and OSP performed serial neuroelectrophysiological assessments. All authors have agreed on the final version.

References

izmir escort bayan izmir rus escort bursa escort bayan rus escort izmir escort porno indir porno izle mobil porno eskişehir escort burdur escort bartın escort havalandırma izmir escort bursa escort türk porno escort bayan