Mood disorders have many forms, from anxiety attacks, depression, Obsessive Compulsive Disorder (OCD) to Post Traumatic Disorder (PTSD). Recently, many studies have shown that zinc may act as a crucial neuromodulator in glutamatergic and GABAergic balance. What’s more, growing evidences considered that zinc be a trait marker of mood disorder. It was reported that zinc deficiency induces depression, while supplementing with this mineral improved mood as well as cognitive function. In this present review, the links of zinc in the mood disorder and zinc in the Alzheimer’s disease were systemically reviewed. It may be helpful for zinc applicantion in clinical thus address zinc as a new target of research for therapy.