Abstract

The role of ROSA navigated intracranial electrode implantation technique on precise epileptogenic zone localization

Author(s): Jian Zhou,Ling-tuan Huang, Feng Zhai, Yu-guang Guan, Min Bao, Meng Zhao, Peng-fei Teng, Shu-hua Chen, Jing Wang, Tianfu Li, Guo-ming Luan

To evaluate the role of ROSA (Robotized Stereotactic Assistant) navigated intracranial electrode implantation on precise epileptogenic zone localization, 40 patients with drug-resistant epilepsy between March 2012 and September 2013 underwent the procedure. Demographics, noninvasive clinical data, complications and seizure-control outcome after resection were retrospectively collected and analyzed. Of the 40 patients surveyed, 29 underwent unilateral implantation, 11 underwent bilateral implantation. 1 patient experienced an intracranial hematoma caused by the implantation, while the remaining patients underwent the prolonged video-EEG (VEEG) monitoring with no complications. Electrodes were preserved, on average, for 11.4 days ( range 4-34 days); Observed clinical seizures, on average, were 9.9 times per patient (range 2-38 times); There were no cerebrospinal fluid leak, Intracranial hematoma, electrodes fracture or patient death, except 1 patient scalp infection (2.6%, scalp infection rate); 37 patients’ seizure onset area was precisely localized; 32 patients underwent stereo-electroencephalography or coagulation (SEEG)-guide resection or coagulation and were followed up for more than 6 months.


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