Abstract

The Polymorphisms of DRD2 141-C Ins/Del Receptor Influenced the Treatment Responses of Schizophrenia Patients

Author(s): Saidah Syamsuddin, Irawan Yusuf , Jayalangkara Tanra, Irfan Idris

ABSTRACT
Polymorphisms of DRD2 receptors lead to vary in the treatment responses of schizophrenia patients.
Objectives: This study carried out to know the association of polymorphisms of DRD2 141-C Del/Ins receptors to the doses needed of antipsychotic drug, length of hospital stay, and improvement of symptoms of schizophrenia patients.

Methods: The 208 of schizophrenia patients recruited in this study, was hospitalized and have given haloperidol (first generation of antipsychotic drug) then the treatment responses were evaluated by CGI score. The genotyping of the blood performed for DRD2 receptors polymorphisms.

Results: This study showed that DD genotype needed higher doses of antipsychotic drugs (p<0,05), have longer hospital stay (p<0,05), and have a minimum improvement of symptoms (p<0,05).

Conclusion: It was concluded that polymorphisms of DRD2 141-C Del/Ins receptors influenced the treatment responses and should be considered when treating schizophrenia patients with haloperidol.