All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Silent synapse activation in epilepsy

Author(s): Zhi-Qin Xi, Xue-Feng Wang, Yida Hu, Kebing Zeng

Epilepsy is a life-threatening chronic disease in a state of neuronal over electric activity. The precise nature of the seizure recurrence has not been clearly. Synapses can be divided into silent and functional synapse.Silent synapses, defined as structural specializations for neurotransmission that do not produce a physiological response in the receiving cell, may occur frequently in neural circuits. Models of synaptic plasticity, such as long-term potentiation (LTP) and long-term depression (LTD) of glutamatergic synapses, are believed to underlie the seizure occurrence. Silent synapses containing only NMDA receptors are transformed within minutes into activated synapses postsynaptically AMPA receptor insertion and presynaptic transmitter releasing (BDNF-Cdc42 (brain derived neurotrophic factor-) signaling, Calcium influx,cAMP(Cyclic Adenosine monophosphate) signal pathway. All previous mentioned genes and proteins were abnormal in epilepsy patients and animal models. Future experimental and clinical studies are needed a better understanding on the mechanisms of silent synapses in epilepsy.


Full-Text | PDF

Share this       

antalya escort

izmir rus escort

bursa escort bayan

antalya escort bayanlar

izmir escort

porno indir

porno izle

beşiktaş escort

eskişehir escort

burdur escort

bartın escort

havalandırma

türk takipçi satın al

smmabi.com

takipbonus.com

izmir escort

bursa escort

türk porno

escort bayan

yabanci porno

takipçi satın al

takipçi satın al

instagram takipçi satın al

instagram beğeni satın al

instagram takipçi satın al

takipçi satın alma

escort

panel smm

takipçi satın al instagram

smm panel

ataköy escort

izmit escort

Ledger Live desktop: Your secure gateway to crypto. Secure your assets with confidence using Ledger Live desktop. Experience a secure gateway that prioritizes the safety of your digital assets, providing peace of mind.