Abstract

Female Wild-Type and APP/PS1 Transgenic Mice Deficient in Sort1 Are Prone to Anxiety-Like Behavior at Older Ages

Author(s): Chun-Sheng Ruan, Larisa Bobrovskaya, Xin-Fu Zhou

Alzheimer’s disease (AD) and anxiety are two concurrent disorders often co-existing in older adults. Interestingly, women are more likely to experience anxiety than men in both general population and AD. To date, the mechanisms underlying the gender differences in the pathogenesis of AD and anxiety disorder are still not clear. Previously, we have found that the deletion of vacuolar protein sorting 10 protein (VPS10P)-domain containing receptor/sortilin